Fatty acid beta-oxidation using acyl-CoA oxidase

Across TCGA cell cohorts, RNA activity of the Fatty acid beta-oxidation using acyl-CoA oxidase pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACOX3, AMACR, and CRAT, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid beta-oxidation using acyl-CoA oxidase activity versus ACOX3 in LUNG_NSCLC_LUSC (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ACOX3 →	+1.086	+0.115	.002	.002	3	12
LARGE_INTESTINE	AMACR →	+1.029	+0.057	.002	.001	3	11
BREAST	CRAT →	+2.682	+0.134	<.001	<.001	3	10
CNS	GSTK1 →	+1.370	+0.131	<.001	<.001	3	10
SOFT_TISSUE	SLC66A3 →	+1.291	+0.069	.002	.009	3	9
LUNG_SCLC	TMEM120A →	+1.147	+0.125	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033540 vs ACOX3 — LUNG_NSCLC_LUSC

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