Fatty acid beta-oxidation using acyl-CoA oxidase

Across TCGA cell cohorts, RNA activity of the Fatty acid beta-oxidation using acyl-CoA oxidase pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACAA1, C11orf24, and SLC4A1AP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid beta-oxidation using acyl-CoA oxidase activity versus ACAA1 in LARGE_INTESTINE (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACAA1 →	+0.804	+0.227	.006	.002	3	6
BLOOD_Leukemia	C11orf24 →	-1.182	-0.204	<.001	<.001	3	5
SKIN	SLC4A1AP →	-0.448	-0.238	.006	<.001	3	5
OESOPHAGUS	CTU2 →	-0.544	-0.200	.002	.002	3	5
SOFT_TISSUE	CSNK1E →	-1.053	-0.369	.009	.005	3	4
BLOOD_Lymphoma	PIK3IP1 →	+1.178	+0.314	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033540 vs ACAA1 — LARGE_INTESTINE

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