Fatty acid beta-oxidation using acyl-CoA oxidase

Across TCGA cell cohorts, RNA activity of the Fatty acid beta-oxidation using acyl-CoA oxidase pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACAA1, HSD17B4, and RPL9, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid beta-oxidation using acyl-CoA oxidase activity versus ACAA1 in URINARY_TRACT (Pearson r = 0.81).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ACAA1 →	+1.783	+0.316	<.001	<.001	3	16
BREAST	HSD17B4 →	+2.230	+0.331	<.001	<.001	2	10
PANCREAS	RPL9 →	-0.578	-0.158	.003	.001	3	7
CNS	PPM1G →	-0.851	-0.199	<.001	<.001	3	7
CNS	RAN →	-0.644	-0.197	.007	.002	3	7
BREAST	EIF3F →	-0.618	-0.223	.009	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033540 vs ACAA1 — URINARY_TRACT

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