Fatty acid beta-oxidation using acyl-CoA dehydrogenase

Across TCGA patient cohorts, RNA activity of the Fatty acid beta-oxidation using acyl-CoA dehydrogenase pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AIFM1, ARPC5, and ACTR2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid beta-oxidation using acyl-CoA dehydrogenase activity versus AIFM1 in UCEC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AIFM1 →	+0.480	+0.083	<.001	.001	3	8
CCRCC	ARPC5 →	-0.263	-0.074	<.001	<.001	3	7
CCRCC	ACTR2 →	-0.193	-0.074	<.001	<.001	3	7
CCRCC	FN1 →	-0.703	-0.074	<.001	<.001	3	7
OV	PPP1R18 →	-0.434	-0.037	<.001	.001	2	8
COAD	ACAD10 →	+0.387	+0.044	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033539 vs AIFM1 — UCEC

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