Fatty acid beta-oxidation using acyl-CoA dehydrogenase

Across TCGA patient cohorts, RNA activity of the Fatty acid beta-oxidation using acyl-CoA dehydrogenase pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAM10, UBE2S, and RANBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid beta-oxidation using acyl-CoA dehydrogenase activity versus ADAM10 in COAD (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ADAM10 →	-0.430	-0.094	<.001	.001	3	5
COAD	UBE2S →	-1.002	-0.115	<.001	<.001	3	5
BRCA	RANBP1 →	-0.738	-0.143	<.001	<.001	3	5
BRCA	ACTR3 →	-0.318	-0.073	.002	.004	3	5
LSCC	KNSTRN →	-0.714	-0.131	<.001	<.001	3	5
BRCA	LRP8 →	-0.652	-0.105	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033539 vs ADAM10 — COAD

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