Fatty acid beta-oxidation using acyl-CoA dehydrogenase

Across TCGA patient cohorts, RNA activity of the Fatty acid beta-oxidation using acyl-CoA dehydrogenase pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACADS, ETFDH, and ALDH6A1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid beta-oxidation using acyl-CoA dehydrogenase activity versus ACADS in BRCA (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ACADS →	+0.584	+0.094	<.001	<.001	3	9
BRCA	ETFDH →	+0.432	+0.121	<.001	<.001	3	7
BRCA	ALDH6A1 →	+0.596	+0.108	<.001	<.001	3	7
CCRCC	SUCLG1 →	+0.287	+0.135	<.001	<.001	3	6
PDAC	SUCLG2 →	+0.502	+0.102	<.001	.001	3	6
COAD	BCKDHB →	+0.497	+0.124	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033539 vs ACADS — BRCA

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