Fatty acid beta-oxidation using acyl-CoA dehydrogenase

Across TCGA cell cohorts, RNA activity of the Fatty acid beta-oxidation using acyl-CoA dehydrogenase pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTSD, TANGO6, and TNFSF13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid beta-oxidation using acyl-CoA dehydrogenase activity versus CTSD in BLOOD_Lymphoma (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CTSD →	+1.362	+0.204	.001	.004	3	5
OVARY	TANGO6 →	-0.987	-0.236	.009	.008	3	4
OVARY	TNFSF13 →	+1.963	+0.251	.004	.006	2	5
OVARY	ANO9 →	+2.105	+0.265	.003	.003	3	4
BREAST	IVD →	+1.070	+0.193	.005	.006	2	5
BREAST	OR1J1 →	+0.177	+0.231	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033539 vs CTSD — BLOOD_Lymphoma

Explore this scatter interactively →