Carbohydrate homeostasis

Across TCGA patient cohorts, RNA activity of the Carbohydrate homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PATL1, RPL5, and BAZ2A_S1783, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate homeostasis activity versus PATL1 in BRCA (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PATL1 →	-0.348	-0.026	<.001	<.001	3	6
BRCA	RPL5 →	-0.292	-0.026	<.001	<.001	3	5
BRCA	BAZ2A_S1783 →	-0.518	-0.020	.001	.001	3	5
BRCA	VIM_S22 →	+0.530	+0.018	<.001	<.001	3	5
BRCA	VIM_S72 →	+0.714	+0.020	<.001	<.001	3	5
BRCA	WDHD1 →	-0.463	-0.022	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033500 vs PATL1 — BRCA

Explore this scatter interactively →