Carbohydrate homeostasis

Across TCGA patient cohorts, RNA activity of the Carbohydrate homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIX4, BPI, and PTGR1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Carbohydrate homeostasis activity versus SIX4 in COAD (Pearson r = -0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SIX4 →	-0.484	-0.281	.007	.002	3	1
COAD	BPI →	-0.246	-0.218	<.001	.003	3	1
COAD	PTGR1 →	+0.868	+0.273	.001	.001	3	1
COAD	B3GAT1 →	-0.160	-0.296	.002	<.001	3	1
COAD	TMIGD3 →	-0.851	-0.311	.001	.002	3	1
COAD	LRRC17 →	-0.840	-0.321	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033500 vs SIX4 — COAD

Explore this scatter interactively →