Carbohydrate homeostasis

Across TCGA cell cohorts, RNA activity of the Carbohydrate homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARSK, WDR54, and CLTA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARSK grouped by Carbohydrate homeostasis-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ARSK →	-0.929	-0.260	.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	WDR54 →	-2.009	-0.237	<.001	<.001	3	4
LUNG_NSCLC_LUAD	CLTA →	-0.787	-0.257	<.001	.008	3	4
LUNG_NSCLC_LUAD	CCN1 →	-1.994	-0.139	.001	.002	3	4
OESOPHAGUS	UBE2O →	+0.563	+0.238	.006	.002	2	5
SOFT_TISSUE	YAP1 →	-0.685	-0.248	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARSK by Carbohydrate homeostasis activity — SOFT_TISSUE

Explore this box plot interactively →