Secretory granule organization

Across TCGA patient cohorts, RNA activity of the Secretory granule organization pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDC80, UCK2, and UBE2S, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Secretory granule organization activity versus NDC80 in UCEC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDC80 →	-0.745	-0.302	.007	.009	3	5
LUAD	UCK2 →	-0.689	-0.205	.001	<.001	3	4
HNSC	UBE2S →	-0.802	-0.116	.001	.004	3	4
UCEC	ZNF695 →	-0.919	-0.509	.001	.002	3	4
BRCA	KIFC1 →	-0.962	-0.174	<.001	<.001	3	4
BRCA	FAM83D →	-1.114	-0.147	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033363 vs NDC80 — UCEC

Explore this scatter interactively →