Secretory granule organization

Across TCGA cell cohorts, RNA activity of the Secretory granule organization pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNTB2, PHLPP2, and GPR108, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNTB2 grouped by Secretory granule organization-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SNTB2 →	-0.655	-1.538	<.001	<.001	3	4
OVARY	PHLPP2 →	-0.959	-1.526	.004	<.001	3	4
BREAST	GPR108 →	-0.451	-0.804	.003	.009	2	5
LUNG_SCLC	DENND4C →	+1.543	+1.203	<.001	.002	3	4
OVARY	NACC2 →	-0.608	-0.910	.005	.003	3	4
OVARY	AP4E1 →	-0.700	-1.329	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNTB2 by Secretory granule organization activity — OESOPHAGUS

Explore this box plot interactively →