Secretory granule organization

Across TCGA cell cohorts, RNA activity of the Secretory granule organization pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHRNA5, MEX3B, and ZNF580, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Secretory granule organization activity versus CHRNA5 in STOMACH (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CHRNA5 →	-1.381	-1.189	.008	.001	3	4
BLOOD_Leukemia	MEX3B →	-1.526	-0.903	<.001	<.001	3	4
LIVER	ZNF580 →	-1.304	-1.405	.002	.002	3	3
KIDNEY	UQCC1 →	+0.895	+1.522	.003	.001	3	3
KIDNEY	ZNF175 →	+1.518	+1.569	.008	.001	3	3
KIDNEY	RNF157 →	-2.007	-1.801	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033363 vs CHRNA5 — STOMACH

Explore this scatter interactively →