S-adenosylmethionine cycle

Across TCGA patient cohorts, RNA activity of the S-adenosylmethionine cycle pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FASN_S207, MRI1, and SLC38A2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, S-adenosylmethionine cycle activity versus FASN_S207 in OV (Pearson r = -0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FASN_S207 →	-0.604	-0.045	.001	<.001	3	6
OV	MRI1 →	+0.410	+0.044	.009	.001	3	6
LUAD	SLC38A2 →	-0.645	-0.051	<.001	<.001	3	6
BRCA	TSTD1 →	+0.381	+0.036	.001	<.001	3	5
LSCC	ADAM9 →	-0.316	-0.033	.002	.001	3	5
LUAD	KIF23_S867 →	-0.893	-0.036	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033353 vs FASN_S207 — OV

Explore this scatter interactively →