S-adenosylmethionine cycle

Across TCGA cell cohorts, RNA activity of the S-adenosylmethionine cycle pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRI1, AKAP8, and CHERP, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, S-adenosylmethionine cycle activity versus MRI1 in URINARY_TRACT (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MRI1 →	+1.441	+0.144	<.001	<.001	3	16
BLOOD_Lymphoma	AKAP8 →	+0.594	+0.103	<.001	<.001	3	10
BLOOD_Lymphoma	CHERP →	+0.846	+0.102	.001	.001	3	10
URINARY_TRACT	KRI1 →	+1.130	+0.149	<.001	<.001	3	10
URINARY_TRACT	RHOT2 →	+0.849	+0.130	.001	<.001	3	9
URINARY_TRACT	ARGLU1 →	+1.291	+0.115	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033353 vs MRI1 — URINARY_TRACT

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