Mitotic DNA replication checkpoint signaling

Across TCGA patient cohorts, RNA activity of the Mitotic DNA replication checkpoint signaling pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC2, RFC3, and RPL12_S38, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic DNA replication checkpoint signaling activity versus RFC2 in BRCA (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RFC2 →	+0.485	+0.090	<.001	<.001	3	9
UCEC	RFC3 →	+0.361	+0.098	<.001	<.001	3	9
LUAD	RPL12_S38 →	+1.158	+0.089	<.001	<.001	3	9
UCEC	RRM2 →	+0.853	+0.108	<.001	<.001	3	9
COAD	RRM1 →	+0.498	+0.040	<.001	<.001	3	9
GBM	ATAD2 →	+0.544	+0.110	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033314 vs RFC2 — BRCA

Explore this scatter interactively →