Mitotic DNA replication checkpoint signaling

Across TCGA patient cohorts, RNA activity of the Mitotic DNA replication checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HPN, ACTR2, and BLOC1S4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic DNA replication checkpoint signaling activity versus HPN in BRCA (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HPN →	-1.911	-0.813	<.001	.005	3	4
OV	ACTR2 →	+0.435	+0.217	.004	.007	3	3
LUAD	BLOC1S4 →	-0.324	-0.914	.002	.004	2	4
GBM	NPM1P31 →	+0.054	+0.766	.004	<.001	3	3
GBM	LINC00475 →	-0.928	-0.629	.003	.003	3	3
OV	THG1L →	-0.543	-0.254	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033314 vs HPN — BRCA

Explore this scatter interactively →