Mitotic DNA replication checkpoint signaling

Across TCGA cell cohorts, RNA activity of the Mitotic DNA replication checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ROGDI, TCTE3, and WNT7B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mitotic DNA replication checkpoint signaling activity versus ROGDI in OESOPHAGUS (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ROGDI →	-0.967	-0.294	.006	.006	3	4
OESOPHAGUS	TCTE3 →	-1.222	-0.469	.001	.002	3	3
UPPER_AERODIGESTIVE_TRACT	WNT7B →	-1.519	-0.415	.004	.001	3	3
OVARY	CENATAC →	-1.588	-0.365	.002	.006	3	3
OESOPHAGUS	SPSB3 →	-1.347	-0.356	.002	.005	3	3
OESOPHAGUS	PCF11 →	-0.645	-0.318	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033314 vs ROGDI — OESOPHAGUS

Explore this scatter interactively →