Meiotic cell cycle checkpoint signaling

Across TCGA patient cohorts, RNA activity of the Meiotic cell cycle checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CIT, SH3BGRL, and SKA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic cell cycle checkpoint signaling activity versus CIT in UCEC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CIT →	+0.647	+0.577	<.001	<.001	3	5
BRCA	SH3BGRL →	-1.326	-0.531	<.001	<.001	3	5
UCEC	SKA1 →	+0.986	+0.608	<.001	<.001	3	5
BRCA	PLK1 →	+0.758	+0.471	<.001	<.001	3	5
UCEC	CDCA2 →	+1.084	+0.692	<.001	<.001	3	5
BRCA	HHAT →	-0.955	-0.696	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033313 vs CIT — UCEC

Explore this scatter interactively →