Meiotic cell cycle checkpoint signaling

Across TCGA cell cohorts, RNA activity of the Meiotic cell cycle checkpoint signaling pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HUS1, TTK, and ANLN, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic cell cycle checkpoint signaling activity versus HUS1 in LUNG_NSCLC_LUSC (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	HUS1 →	+1.012	+0.232	<.001	<.001	3	15
BREAST	TTK →	+1.231	+0.157	<.001	<.001	3	15
CNS	ANLN →	+1.404	+0.138	<.001	<.001	3	13
PANCREAS	MTFR2 →	+0.883	+0.154	<.001	<.001	3	11
CNS	FIGNL1 →	+0.999	+0.097	<.001	.002	3	11
BLOOD_Lymphoma	PSMA2 →	+0.776	+0.113	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033313 vs HUS1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →