T-tubule organization

Across TCGA patient cohorts, RNA activity of the T-tubule organization pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHRDL1, COL14A1, and ANK2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T-tubule organization activity versus CHRDL1 in HNSC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CHRDL1 →	+1.599	+1.146	<.001	<.001	3	7
BRCA	COL14A1 →	+1.541	+0.948	.001	.002	3	6
CCRCC	ANK2 →	+1.329	+0.869	<.001	<.001	3	6
LSCC	ADH1B →	+1.295	+0.745	<.001	<.001	3	6
LSCC	AQP1 →	+0.784	+0.641	<.001	<.001	3	6
LSCC	RASGRP2 →	+0.786	+0.867	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033292 vs CHRDL1 — HNSC

Explore this scatter interactively →