T-tubule organization

Across TCGA cell cohorts, RNA activity of the T-tubule organization pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGLYRP2, ARL2, and CDC42, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PGLYRP2 grouped by T-tubule organization-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PGLYRP2 →	-0.215	-0.189	.009	.004	2	5
BLOOD_Myeloma	ARL2 →	-0.385	-1.425	<.001	.002	3	3
STOMACH	CDC42 →	-0.501	-0.387	.009	<.001	3	3
LUNG_NSCLC_LUAD	NRAP →	-0.143	-0.516	.005	.005	3	3
BLOOD_Myeloma	CLEC10A →	+0.407	+1.738	.004	<.001	3	3
BLOOD_Leukemia	AQP5 →	-0.223	-1.350	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PGLYRP2 by T-tubule organization activity — KIDNEY

Explore this box plot interactively →