Cell proliferation in midbrain

Across TCGA patient cohorts, RNA activity of the Cell proliferation in midbrain pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WNT5A, COL1A2, and RAI14, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell proliferation in midbrain activity versus WNT5A in OV (Pearson r = 0.00).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WNT5A →	+1.071	+0.150	<.001	<.001	3	6
BRCA	COL1A2 →	+0.685	+0.062	<.001	.003	3	6
PDAC	RAI14 →	+0.205	+0.108	<.001	<.001	3	6
OV	SRPX2 →	+0.669	+0.069	<.001	.009	3	5
PDAC	FBN2 →	+0.654	+0.107	<.001	<.001	3	5
UCEC	TMEM87A →	+0.299	+0.082	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033278 vs WNT5A — OV

Explore this scatter interactively →