Actin-myosin filament sliding

Across TCGA patient cohorts, RNA activity of the Actin-myosin filament sliding pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPM1, MYL6B, and PCF11, each associated with the pathway in up to 21 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin-myosin filament sliding activity versus TPM1 in SCLC (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	TPM1 →	+1.980	+0.282	<.001	<.001	2	21
UCS	MYL6B →	+1.492	+0.262	<.001	<.001	3	19
ACC	PCF11 →	-0.659	-0.085	<.001	<.001	3	17
ACC	RBM33 →	-0.563	-0.085	.002	<.001	3	17
CESC	LTB4R2 →	-0.850	-0.060	<.001	<.001	3	17
OV	MCM3AP-AS1 →	-0.327	-0.064	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033275 vs TPM1 — SCLC

Explore this scatter interactively →