Actin-myosin filament sliding

Across TCGA patient cohorts, RNA activity of the Actin-myosin filament sliding pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FILIP1L_S791, AIMP2, and FILIP1L_S1035, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin-myosin filament sliding activity versus FILIP1L_S791 in GBM (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FILIP1L_S791 →	+0.447	+0.081	.001	.001	3	5
CCRCC	AIMP2 →	+0.113	+0.079	<.001	.008	3	5
LSCC	FILIP1L_S1035 →	+0.392	+0.082	.006	<.001	3	4
HNSC	MYL6B →	+1.414	+0.163	<.001	<.001	3	4
HNSC	SAMD12 →	-0.534	-0.165	.001	.001	3	4
HNSC	UGP2 →	+0.376	+0.171	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033275 vs FILIP1L_S791 — GBM

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