Actin-myosin filament sliding

Across TCGA patient cohorts, RNA activity of the Actin-myosin filament sliding pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP20, SGCA, and CAP2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin-myosin filament sliding activity versus ARHGAP20 in UCEC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARHGAP20 →	+0.616	+0.191	.006	<.001	3	7
HNSC	SGCA →	+1.049	+1.763	<.001	<.001	3	5
HNSC	CAP2 →	+0.682	+1.307	<.001	<.001	3	5
UCEC	PRRX1 →	+0.888	+0.220	.004	<.001	3	5
HNSC	CASQ2 →	+2.067	+1.659	<.001	<.001	3	5
HNSC	TGFB3 →	+0.835	+1.632	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033275 vs ARHGAP20 — UCEC

Explore this scatter interactively →