Actin-myosin filament sliding

Across TCGA cell cohorts, RNA activity of the Actin-myosin filament sliding pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPM1, THBS1, and JPH2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin-myosin filament sliding activity versus TPM1 in BONE (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TPM1 →	+4.440	+0.474	.002	<.001	3	7
LIVER	THBS1 →	+4.315	+0.322	.003	.001	3	7
LIVER	JPH2 →	+2.668	+0.329	.004	<.001	3	7
BONE	STBD1 →	+2.052	+0.468	.002	<.001	3	6
LIVER	LEPROT →	+1.276	+0.403	.008	<.001	3	6
LIVER	RTN4 →	+0.775	+0.379	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033275 vs TPM1 — BONE

Explore this scatter interactively →