Regulation of nuclear cell cycle DNA replication

Across TCGA patient cohorts, RNA activity of the Regulation of nuclear cell cycle DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAS1L, NCF1B, and SH3GLB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nuclear cell cycle DNA replication activity versus LAS1L in LSCC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LAS1L →	+0.336	+0.661	<.001	<.001	3	5
GBM	NCF1B →	-0.893	-0.591	<.001	.003	3	5
BRCA	SH3GLB1 →	-0.374	-0.320	.003	.006	3	4
BRCA	RGCC →	-0.666	-0.287	.005	.001	3	4
LSCC	GOT2P7 →	-0.502	-0.771	<.001	<.001	3	4
LSCC	ZFP30 →	+0.642	+0.824	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033262 vs LAS1L — LSCC

Explore this scatter interactively →