Regulation of nuclear cell cycle DNA replication

Across TCGA cell cohorts, RNA activity of the Regulation of nuclear cell cycle DNA replication pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAGEE1, PHF20, and C16orf91, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nuclear cell cycle DNA replication activity versus MAGEE1 in LIVER (Pearson r = 0.96).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MAGEE1 →	+2.525	+0.381	.004	.001	3	3
LIVER	PHF20 →	+0.944	+0.373	.005	.002	3	3
BLOOD_Leukemia	C16orf91 →	+0.386	+0.230	.002	.004	3	3
STOMACH	PAAF1 →	+1.189	+2.373	.008	<.001	3	3
STOMACH	PIK3R4 →	+0.638	+1.347	.001	.004	3	3
BREAST	SAXO1 →	+0.056	+0.591	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033262 vs MAGEE1 — LIVER

Explore this scatter interactively →