Regulation of nuclear cell cycle DNA replication

Across TCGA cell cohorts, RNA activity of the Regulation of nuclear cell cycle DNA replication pathway is significantly associated with the protein abundance of multiple proteins, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DACH1, PDXK, and WIZ, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nuclear cell cycle DNA replication activity versus DACH1 in STOMACH (Pearson r = 0.95).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DACH1 →	+4.689	+2.409	<.001	<.001	3	6
LUNG_NSCLC_LUAD	PDXK →	-1.670	-0.856	.002	.005	3	5
BREAST	WIZ →	+0.636	+0.606	<.001	<.001	3	5
LUNG_NSCLC_LUAD	MTHFD1 →	-1.639	-1.246	<.001	.001	3	4
LUNG_NSCLC_LUAD	PLEKHA4 →	-1.193	-0.843	.001	.005	3	4
LUNG_NSCLC_LUAD	PRDX1 →	-0.958	-0.729	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033262 vs DACH1 — STOMACH

Explore this scatter interactively →