Negative regulation of amine metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of amine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARRB2, SPN, and TNFAIP8L2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of amine metabolic process activity versus ARRB2 in LSCC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ARRB2 →	+0.431	+0.143	<.001	<.001	3	10
OV	SPN →	+0.778	+0.095	<.001	<.001	3	10
GBM	TNFAIP8L2 →	+0.607	+0.121	<.001	<.001	3	10
UCEC	WDFY4 →	+0.549	+0.153	<.001	<.001	3	10
LSCC	WIPF1 →	+0.391	+0.121	<.001	<.001	3	10
GBM	CD163 →	+0.810	+0.121	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033239 vs ARRB2 — LSCC

Explore this scatter interactively →