Negative regulation of amine metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of amine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PBDC1, ARPC5, and ESYT3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PBDC1 grouped by Negative regulation of amine metabolic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PBDC1 →	-1.575	-0.446	<.001	<.001	3	4
CNS	ARPC5 →	-0.970	-0.586	.005	.007	3	4
OVARY	ESYT3 →	+0.745	+0.520	.004	.007	3	4
LARGE_INTESTINE	ZNF714 →	+1.137	+0.778	.001	.008	3	4
SOFT_TISSUE	NPDC1 →	-3.045	-0.309	<.001	<.001	3	3
LUNG_NSCLC_LUAD	WDR5B →	-0.348	-0.288	.007	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PBDC1 by Negative regulation of amine metabolic process activity — SOFT_TISSUE

Explore this box plot interactively →