Negative regulation of amine metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of amine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R9B, TMTC1, and DENND1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of amine metabolic process activity versus PPP1R9B in PANCREAS (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PPP1R9B →	+1.162	+0.680	.005	.006	3	4
OVARY	TMTC1 →	+2.976	+1.411	.004	.002	3	4
BLOOD_Leukemia	DENND1B →	+1.030	+1.159	<.001	<.001	3	4
SKIN	MRPL44 →	+0.585	+0.942	<.001	<.001	3	3
SKIN	ZADH2 →	+1.116	+1.262	<.001	.003	3	3
OVARY	ZNF394 →	+0.872	+1.380	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033239 vs PPP1R9B — PANCREAS

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