Positive regulation of protein sumoylation

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein sumoylation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCOR3, RPRD2, and HDAC4_S467, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein sumoylation activity versus RCOR3 in HNSC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RCOR3 →	+0.373	+0.077	<.001	<.001	3	5
LSCC	RPRD2 →	+0.260	+0.052	<.001	<.001	3	5
LSCC	HDAC4_S467 →	+0.303	+0.046	<.001	<.001	3	5
LSCC	MEFV_S179 →	-0.884	-0.050	<.001	<.001	3	5
UCEC	RBMX_S88 →	+0.241	+0.048	.002	.001	3	5
GBM	GATAD2B →	+0.278	+0.043	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033235 vs RCOR3 — HNSC

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