Positive regulation of protein sumoylation

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein sumoylation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL13, RPL30, and KANSL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein sumoylation activity versus RPL13 in CCRCC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RPL13 →	+0.409	+0.460	.004	.001	3	4
UCEC	RPL30 →	+0.999	+0.121	.003	.003	3	3
UCEC	KANSL3 →	+0.232	+0.136	.005	<.001	3	3
UCEC	RPL5 →	+0.514	+0.100	.004	.004	3	3
UCEC	DMAC1 →	+0.532	+0.116	.004	.007	3	3
UCEC	TAF1 →	+0.309	+0.111	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033235 vs RPL13 — CCRCC

Explore this scatter interactively →