Positive regulation of protein sumoylation

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein sumoylation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRFIP1, PTPRCAP, and RRP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LRRFIP1 grouped by Positive regulation of protein sumoylation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	LRRFIP1 →	-1.119	-0.259	<.001	.001	3	4
BREAST	PTPRCAP →	+0.901	+0.489	.005	.003	3	4
PANCREAS	RRP1 →	-0.861	-0.357	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PVR →	-0.853	-0.213	.003	.002	3	4
BREAST	CTSL →	-1.670	-0.455	.001	.006	3	4
BREAST	UNC119B →	+0.799	+0.349	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LRRFIP1 by Positive regulation of protein sumoylation activity — BONE

Explore this box plot interactively →