Positive regulation of protein sumoylation

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein sumoylation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DEPDC5, C5orf46, and PGAM5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein sumoylation activity versus DEPDC5 in OESOPHAGUS (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DEPDC5 →	+0.872	+0.477	<.001	.001	2	6
LARGE_INTESTINE	C5orf46 →	-0.152	-0.287	.003	.001	3	5
PANCREAS	PGAM5 →	+0.733	+0.756	.002	.004	3	5
PANCREAS	BAZ1B →	+0.612	+0.391	.007	.002	2	6
LUNG_SCLC	GADD45B →	-1.909	-0.321	.003	.002	3	5
SKIN	RRAGD →	+1.741	+0.265	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033235 vs DEPDC5 — OESOPHAGUS

Explore this scatter interactively →