Regulation of protein sumoylation

Across TCGA patient cohorts, RNA activity of the Regulation of protein sumoylation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZNF687, RCOR3, and ZMYM3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein sumoylation activity versus ZNF687 in LSCC (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZNF687 →	+0.255	+0.037	<.001	<.001	3	6
HNSC	RCOR3 →	+0.474	+0.074	<.001	<.001	3	6
HNSC	ZMYM3 →	+0.347	+0.054	<.001	<.001	3	5
HNSC	ZNF638 →	+0.251	+0.069	<.001	<.001	3	5
LSCC	DHX9 →	+0.178	+0.032	<.001	<.001	3	5
GBM	GATAD2B →	+0.252	+0.033	.005	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033233 vs ZNF687 — LSCC

Explore this scatter interactively →