Regulation of protein sumoylation

Across TCGA patient cohorts, RNA activity of the Regulation of protein sumoylation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TXN2P1, MTR, and CUTC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein sumoylation activity versus TXN2P1 in BRCA (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TXN2P1 →	+0.226	+0.119	.002	.006	3	4
LSCC	MTR →	+0.381	+0.186	.001	<.001	3	4
OV	CUTC →	+0.499	+0.190	.001	<.001	3	4
OV	DUS3L →	+0.501	+0.136	.002	.001	3	4
PDAC	GNL3L →	+0.189	+0.116	.001	.007	3	4
PDAC	RN7SL143P →	-0.405	-0.154	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033233 vs TXN2P1 — BRCA

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