Regulation of protein sumoylation

Across TCGA cell cohorts, RNA activity of the Regulation of protein sumoylation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALM3, HIRA, and RBM15B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein sumoylation activity versus CALM3 in SOFT_TISSUE (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CALM3 →	+0.873	+0.311	.001	.001	3	7
KIDNEY	HIRA →	+1.346	+0.214	.001	.006	3	6
STOMACH	RBM15B →	+1.024	+0.309	.001	.003	3	5
KIDNEY	SPRING1 →	+1.225	+0.260	.003	.009	3	5
URINARY_TRACT	TRERF1 →	+0.992	+0.507	.003	.003	3	5
OESOPHAGUS	CLASP2 →	+0.972	+0.354	.006	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033233 vs CALM3 — SOFT_TISSUE

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