Iron import into cell

Across TCGA patient cohorts, RNA activity of the Iron import into cell pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GXYLT2, NBL1, and HEXA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Iron import into cell activity versus GXYLT2 in CCRCC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GXYLT2 →	+1.578	+0.498	<.001	.006	3	4
PDAC	NBL1 →	+0.399	+0.177	<.001	.001	3	4
OV	HEXA →	+0.301	+0.121	.006	.008	3	4
LSCC	FAM166C →	-0.443	-0.153	.009	.005	2	4
BRCA	CENPA →	-0.559	-0.314	.007	.001	3	3
BRCA	CEP55 →	-0.664	-0.420	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033212 vs GXYLT2 — CCRCC

Explore this scatter interactively →