Adiponectin-activated signaling pathway

Across TCGA patient cohorts, RNA activity of the Adiponectin-activated signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2_S102, TNS2_S120, and PRELP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adiponectin-activated signaling pathway activity versus TNS2_S102 in GBM (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TNS2_S102 →	+0.578	+0.067	<.001	<.001	3	6
HNSC	TNS2_S120 →	+0.512	+0.057	<.001	<.001	3	6
BRCA	PRELP →	+0.837	+0.044	.001	<.001	3	6
BRCA	ERC1 →	+0.323	+0.032	.001	<.001	3	5
LUAD	AKAP12_T1116 →	+0.575	+0.036	<.001	<.001	2	6
PDAC	GNG7 →	+0.450	+0.040	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033211 vs TNS2_S102 — GBM

Explore this scatter interactively →