Adiponectin-activated signaling pathway

Across TCGA patient cohorts, RNA activity of the Adiponectin-activated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTRT3, TNS2, and SLC27A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adiponectin-activated signaling pathway activity versus ACTRT3 in LSCC (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ACTRT3 →	-0.587	-0.222	.003	.008	3	3
HNSC	TNS2 →	+0.577	+0.333	<.001	.008	3	3
HNSC	SLC27A1 →	+0.514	+0.445	<.001	.001	3	3
BRCA	C3orf18 →	+0.730	+0.224	.005	.007	3	3
UCEC	DICER1-AS1 →	+0.319	+0.352	.006	.005	3	3
PDAC	FNDC3CP →	+0.207	+0.316	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033211 vs ACTRT3 — LSCC

Explore this scatter interactively →