Leptin-mediated signaling pathway

Across TCGA patient cohorts, RNA activity of the Leptin-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHLDB3, CES4A, and TSEN2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leptin-mediated signaling pathway activity versus PHLDB3 in OV (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PHLDB3 →	+0.445	+0.117	.002	.008	3	3
CCRCC	CES4A →	+0.968	+0.178	.002	.004	3	3
CCRCC	TSEN2 →	+0.280	+0.196	.001	.002	3	3
CCRCC	ANKZF1 →	+0.438	+0.251	<.001	<.001	3	3
CCRCC	OR2A4 →	+0.919	+0.185	<.001	<.001	3	3
CCRCC	EEF1A1P30 →	+0.435	+0.196	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033210 vs PHLDB3 — OV

Explore this scatter interactively →