Leptin-mediated signaling pathway

Across TCGA cell cohorts, RNA activity of the Leptin-mediated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIRT6, NAA20, and FSTL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SIRT6 grouped by Leptin-mediated signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SIRT6 →	-0.606	-0.979	.001	<.001	3	5
BONE	NAA20 →	-0.572	-1.287	.007	.007	3	4
LIVER	FSTL3 →	-2.658	-1.566	.002	<.001	3	4
URINARY_TRACT	KAT14 →	-0.765	-1.727	.002	<.001	3	4
CNS	TMEM160 →	+1.133	+0.960	<.001	<.001	3	3
CNS	LRRCC1 →	+0.793	+0.941	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SIRT6 by Leptin-mediated signaling pathway activity — BLOOD_Leukemia

Explore this box plot interactively →