Meiotic cytokinesis

Across TCGA patient cohorts, RNA activity of the Meiotic cytokinesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOK3, FERMT3, and BIN2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic cytokinesis activity versus DOK3 in GBM (Pearson r = -0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DOK3 →	-0.421	-0.045	<.001	<.001	3	7
GBM	FERMT3 →	-0.350	-0.052	.002	<.001	3	7
GBM	BIN2 →	-0.368	-0.040	.002	.002	3	6
GBM	FMNL1 →	-0.485	-0.068	.008	<.001	3	6
HNSC	GMFG →	-0.445	-0.049	<.001	.007	3	6
GBM	APBB1IP →	-0.491	-0.058	.007	.005	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033206 vs DOK3 — GBM

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