Meiotic cytokinesis

Across TCGA patient cohorts, RNA activity of the Meiotic cytokinesis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL22RA1, MCCC2, and CDK2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic cytokinesis activity versus IL22RA1 in UCEC (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IL22RA1 →	-0.549	-0.963	<.001	<.001	3	3
BRCA	MCCC2 →	-0.701	-0.088	.001	.002	3	3
LUAD	CDK2 →	-0.403	-0.103	<.001	.004	3	3
LUAD	MELK →	-0.904	-0.118	.005	.008	3	3
LUAD	PARPBP →	-0.600	-0.115	<.001	.002	3	3
GBM	HMGN1P17 →	-0.231	-0.605	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033206 vs IL22RA1 — UCEC

Explore this scatter interactively →