Response to ATP

Across TCGA patient cohorts, RNA activity of the Response to ATP pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1QA, C1R, and NNMT, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ATP activity versus C1QA in GBM (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	C1QA →	+0.551	+0.052	<.001	<.001	3	8
LSCC	C1R →	+0.545	+0.050	<.001	<.001	3	8
OV	NNMT →	+0.993	+0.029	.002	.004	3	8
GBM	FAP →	+0.747	+0.073	<.001	<.001	3	8
GBM	COPZ2 →	+0.660	+0.054	<.001	<.001	3	8
LSCC	RCN3 →	+0.596	+0.061	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033198 vs C1QA — GBM

Explore this scatter interactively →