Response to ATP

Across TCGA patient cohorts, RNA activity of the Response to ATP pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B4GALT5, SDR9C7, and NEFH, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ATP activity versus B4GALT5 in GBM (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	B4GALT5 →	-0.453	-0.372	.001	<.001	3	3
CCRCC	SDR9C7 →	-0.079	-0.826	<.001	<.001	3	3
HNSC	NEFH →	+0.319	+0.557	<.001	.002	3	2
HNSC	PMP22 →	+0.786	+0.733	.001	<.001	3	2
HNSC	ADAMTS5 →	+0.684	+0.653	.007	<.001	3	2
HNSC	RAB3IL1 →	+0.422	+0.376	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033198 vs B4GALT5 — GBM

Explore this scatter interactively →