Response to ATP

Across TCGA cell cohorts, RNA activity of the Response to ATP pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COQ9, MARS2, and FAM217A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to ATP activity versus COQ9 in LUNG_SCLC (Pearson r = -0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	COQ9 →	-0.810	-0.252	<.001	.003	3	5
STOMACH	MARS2 →	-0.988	-0.324	.009	.005	3	5
LUNG_NSCLC_LUAD	FAM217A →	+0.275	+0.158	.001	.009	3	5
STOMACH	KLHDC4 →	-0.609	-0.223	.007	.003	3	5
LIVER	FAM20C →	+3.643	+0.332	.002	.003	3	4
BONE	PAXIP1 →	-1.448	-0.326	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0033198 vs COQ9 — LUNG_SCLC

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